Catalytic multi-step domino and one-pot reactions

• Svetlana B. Tsogoeva

Beilstein J. Org. Chem. 2024, 20, 254–256, doi:10.3762/bjoc.20.25

• triggers the next, which in the end yields a complex product. In contrast to a conventional “stop-and-go” method, only a single workup and purification is needed (Figure 1b), and therefore these reaction cascades can be considered superior to stepwise synthetic approaches in the context of green chemistry

Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids

• Melodi Demiray,
• David J. Miller and
• Rudolf K. Allemann

Beilstein J. Org. Chem. 2019, 15, 2184–2190, doi:10.3762/bjoc.15.215

• -FDPs to sesquiterpenoids that may have applications in healthcare and agriculture. These results inform us of both the utility and limitations that non-natural functional groups have upon terpene cyclase-catalysed reaction cascades supporting the design of future biocatalytic syntheses. In particular

Back to the future: Why we need enzymology to build a synthetic metabolism of the future

• Tobias J. Erb

Beilstein J. Org. Chem. 2019, 15, 551–557, doi:10.3762/bjoc.15.49

• synthetic metabolic networks From above examples it becomes evident that for building completely novel pathways and/or complex reaction cascades, resources are required that provide synthetic biologists with the information to find individual enzymes for a given synthetic metabolic network. More than 116

Atom-economical group-transfer reactions with hypervalent iodine compounds

• Andreas Boelke,
• Peter Finkbeiner and
• Boris J. Nachtsheim

Beilstein J. Org. Chem. 2018, 14, 1263–1280, doi:10.3762/bjoc.14.108

• scope of this transformation is broad, only C2-substituted indoles show poor reactivity. Furthermore, this is a rare example for good chemoselectivities in atom-efficient reaction cascades even if unsymmetrical substituted diaryliodonium salts are applied. Based on this initial procedure, an impressive

Coupled chemo(enzymatic) reactions in continuous flow

• Ruslan Yuryev,
• Simon Strompen and
• Andreas Liese

Beilstein J. Org. Chem. 2011, 7, 1449–1467, doi:10.3762/bjoc.7.169

• . Three different approaches to such reaction systems are presented herein and discussed in view of their advantages and disadvantages as well as trends for their future development. Keywords: biocatalysis; chemo-enzymatic reaction sequences; continuous flow; coupled reactions; reaction cascades

• become reality: In the last few decades the concept of reaction cascades has become increasingly popular and has been proven to be a viable synthetic route to many classes of organic compounds [13][14][15]. Biotransformations consisting of coupled sequential and/or parallel reactions catalyzed by one or

• . This principle has been recently utilized in applied biocatalysis for the development of novel types of catalysts for multistep reaction cascades, i.e., metabolon catalysts [55], self-assembled fusion protein complexes [56] and polymerosomes [57]. It is very probable that application of these novel